Cryo-EM, X-ray diffraction, and atomistic simulations reveal determinants for the formation of a supramolecular myelin-like proteolipid lattice

Ruskamo, S., Krokengen, O.C., Kowal, J., Nieminen, T., Lehtimäki, M., Raasakka, A., Dandey, V., Vattulainen, I., Stahlberg, H., Kursula, P.

(submitted), (2020)

New insights on the structure of alpha-synuclein fibrils using cryo-electron microscopy

Guerrero-Ferreira, R., Kovacik, L., Ni, D., Stahlberg, H.

Current Opinion in Neurobiology 61, 89-95 (2020)

Grayscale e-beam lithography: Effects of a delayed development for well-controlled 3D patterning

Mortelmans, T., Kazasiz, D., Guzenko, V.A., Padeste, C., Braun, T., Stahlberg, H., Li, X., Ekinci, Y.

Microelectronic Engineering (in press), (2020)

Cryo ptychographic ...

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A helical inner scaffold provides a structural basis for centriole cohesion

Le Guennec, M., Klena, N., Gambarotto, D., Laporte, M.H., Tassin, A.M., van den Hoek, H., Erdmann, P.S., Schaffer, M., Kovacik, L., Borgers, S., Goldie, K., Stahlberg, H., Bornens, M., Azimzadeh, J., Engel, B.D., Hamel, V., Guichard, P.

Science Advances 6(7), eaaz4137 (2020)

Inner-membrane GspF of the bacterial type II secretion system is a dimeric adaptor mediating pseudopilus biogenesis

Van Putte, W., De Vos, T., Vanden Broeck, W., Stahlberg, H., Kudryashev, M., Savvides, S.N.

(submitted), (2020)

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Single particle analysis for high resolution 2D electron crystallography

Righetto, R., Stahlberg, H.

Methods in Mol. Biology. (submitted), (2020)

Design guidelines for an electron diffractometer for structural chemistry and structural biology.

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Acta Crystallogr D Struct Biol 75(Pt 5), 458-466 (2019)

DuoMab: a novel CrossMab-based IgG-derived antibody format for enhanced antibody-dependent cell-mediated cytotoxicity

Sustmann, C., Dickopf, S., Regula, J.T., Kettenberger, H., Mølhøj, M., Gassner, C., Weininger, D., Fenn, S., Manigold, T., Kling, L., Künkele, K.P., Schwaiger, M., Bossenmaier, B., Griese, J.J., Hopfner, K.P., Graff, A., Stahlberg, H., Ringler, P., Lauer, M.E., Brinkmann, U., Schaefer, W., Klein, C.

MAbs 11(8), 1402-1414 (2019)

Diverse roles of TssA-like proteins in the assembly of bacterial type VI secretion systems

Schneider, J.P., Nazarov, S.50, Liuzzo, M., Ringel, P.D., Stahlberg, H., Basler, M.

EMBO J. 38: e100825, 1-17 (2019)

Two new polymorphic structures of alpha-synuclein solved by cryo-electron microscopy

Guerrero-Ferreira, R., Taylor, N., Arteni, A.-A., Kumari, P., Mona, D., Ringler, P., Britschgi, M., Lauer, M.E., Verasdock, J., Riek, R., Melki, R., Meier, B.H., Böckmann, A., Bousset, L., Stahlberg, H.

eLife 8:e48907, (2019)

1 kHz fixed-target serial crystallography using a multilayer monochromator and an integrating pixel detector

Tolstikova, A., Levantino, M., Yefanov, O., Hennicke, V., Fischer, P., Meyer, J., Mozzanica, A., Redford, S., Crosas, E., Opara, N., Barthelmess, M., Lieske, J., Oberthuer, D., Wator, E., Mohacsi, I., Wulff, M., Schmitt, B., Chapman, H., Meents, A.

IUCr Journals 6(5), 927-937 (2019)

Generation, Characterization, and Quantitative Bioanalysis of Drug/Anti-drug Antibody Immune Complexes to Facilitate Dedicated In Vivo Studies

Hoffmann, e., Jordan, G., Lauer, M., Ringler, P., Kusznir, E.A., Rufer, A.C., Huber, S., Jochner, A., Winter, G., Staack, R.F.

Pharm. Res. 36:129, 1-15 (2019)

Cryo-EM structure of the rhodopsin-G-alpha-i-beta-gamma complex reveals binding of the rhodopsin C-terminal tail to the G-beta subunit

Tsai, C.J., Marino, J., Adaixo, R., Pamula, F., Muehle, J., Maeda, S., Flock, T., Taylor, N., Mohammed, I., Matile, H., Dawson, R.J.P., Deupi, X., Stahlberg, H., Schertler, G.F.X.

eLife 8;e46041, (2019)

Lewy pathology in Parkinson's disease consists of crowded organelles and lipid membranes

Shahmoradian, S., Lewis, A., Genoud, C., Graff, A., Pérez Navarro, P., Goldie, K., Sütterlin, R., Castano-Diez, D., Ingrassia, A., Rozemuller, A.J.M., Paepe, A.D., Erny, J.Staempfli, A., Hoernschemeyer, J., Niedieker, D., El-Mashtoly, S.F., Gerwert, K., Bohrmann, B., Britschgi, M., Stahlberg, H., van de Berg, W.D.J., Lauer, M.E.

Nature Neuroscience 22, 1099-1109 (2019)

‘Differential visual proteomics’: Enabling the proteome-wide comparison of protein structures of single-cells

Syntychaki, A., Rima, L., Schmidli, C., Stohler, T., Bieri, A., Sütterlin, R., Stahlberg, H., Castano-Diez, D., Braun, T.

J. of Proteome Research 18(9), 3521-3531 (2019)

Imaging of post-mortem human brain tissue using electron and X-ray microscopy

Lewis, A., Genoud, C., Pont, M., van de Berg, W.D.J., Frank, S., Stahlberg, H., Shahmoradian, S., Al-Amoudi, A.

Current Opinion Structural Biology 58, 138-148 (2019)

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy

Claus, C., Ferrara, C., Xu, W., Sam, J., Lang, S., Uhlenbrock, F., Albrecht, R., Herter, S., Schlenker, R., Hüsser, T., Diggelmann, S., Challier, J., Mössner, E., Hosse, RJ., Hofer, T., Brünker, P., Joseph, C., Benz, J., Ringler, P., Stahlberg, H., Lauer, M., et al., Klein, C., Umana, P.

Science Translational Medicine 11(496), 1-12 (2019)

Microfluidic protein isolation and sample preparation for high resolution cryo-EM

Schmidli, C., Albiez, S., Rima, L., Righetto, R., Mohammed, I., Oliva, P., Kovacik, L., Stahlberg, H., Braun, T.

PNAS 116(30), 15007-15012 (2019)

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Piper, S., Brillault, L., Rothnagel, R., Croll, T., Box, J., Chassagnon, I., Scherer, S., Goldie, K., Jones, S., Schepers, F., Hartley-Tassell, L., Ve, T., Busby, J., Dalziel, J., Lott, S., Hankamer, B., Stahlberg, H., Hurst, M., Landsberg, M

Nature Communications 10(1), 1952 (2019)

Microfabricated silicon chip as lipid membrane sample holder for serial protein crystallography

Gorzny, M.L., Opara, N., Guzenko, V.A., Cadarso, V.J., Schift, H., Li, X.D., Padeste, C.

Micro Nano Engineering 3, 31-36 (2019)

Array based real-time measurement of fluid viscosities and mass-densities to monitor biological filament formation

Oliva, P., Bircher, B., Schönenberger, C.-A., Braun, T.

Lab on a Chip 19(7), 1305-1314 (2019)

Deuterium induces a distinctive Escherichia coli proteome that correlates with the reduction in growth rate.

Opitz, C., Ahrne, E., Goldie, K., Schmidt, A., Grzesiek, S

J. Biol. Chem. 294(7), 2279-2292 (2019)

Femtosecond phase-transition in hard x-ray excited bismuth

Makita, M., Vartiainen, Mohacsi, Caleman, Diaz, Joensson, Juranic, Medvedev, Meents, Mozzanica, Opara, N., Padeste, C., Panneels, Saxena, Sikorski, Song, Vera, Willmott, Beaud, Milne, Ziaja-Motyka, David, C.

Scientific Reports 9(602), (2019)

Cryo-EM structure of phosphodiesterase 6 reveals insights into the allosteric regulation of type I phosphodiesterases

Gulati, Palczewski, K., Engel, A., Stahlberg, H., Kovacik, L.

Science Advances 5(2), eaav4322 (2019)

Retrieving high-resolution information from disordered 2D crystals by single particle cryo-EM

Righetto, R., Biyani, N., Kowal, J., Chami, M., Stahlberg, H.

Nature Communications 10(1), 1722 (2019)

Supramolecular architectures of molecularly thin yet robust free-standing layers

Moradi, M., Opara, N., Tulli, L.G., Wäckerlin, C., Dalgarno, S.J., Teat, S.J., Baljozovic, M., Popova, O., van Genderen, E., Kleibert, A., Stahlberg, H., Abrahams, J., Padeste, C., Corvini, P.F.-X., Jung, T.A., Shahgaldian, P.

Science Advances 5(2), eaav4489 (2019)

Molecular structure and function of myelin protein P0 in membrane stacking

Raasakka, A., Ruskamo, S., Kowal, J., Han, H., Baumann, A., Myllykoski, M., Fasano, A., Rossano, R., Riccio, P., Buerck, J., Ulrich, A.S., Stahlberg, H., Kursula, P.

Scientific Reports 9(462), (2019)

TDP-43 extracted from FTLD patient brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates

Laferriere, F., Maniecka, Perez-Berlanga, Hruska-Plochan, Gilhespy, Hock, Wagner, Afroz, Boersema, Barmettler, Foti, Asi, Isaacs, Al-Amoudi, A., Lewis, A., Stahlberg, H., Ravits, De Giorgi, Ichas, Bezard, Picotti, P., Lashley, T., Polymenidou, M.

Nature Neuroscience 22, 65-77 (2019)

Part 2: Coping with Biology

Benjamin Stecher. (Images:, Lewis, A., Shahmoradian, S., Stahlberg, H., )

Tomorrow Edition (an online blog by Benjamin Stecher about his journey in Parkinson's disease), (2018)

Rapid Structure Determination of Microcrystalline Molecular Compounds Using Electron Diffraction.

Gruene, T., Wennmacher, JTC, Zaubitzer, C, Holstein, JJ, Heidler, J, Fecteau-LeFebvre, A., De Carlo, S, Mueller, E, Goldie, K., Regeni, I, Li, T, Santiso-Quinones, G, Steinfeld, G, Handschin, S, van Genderen, E., van Bokhoven, JA, Clever, GH, Pantelic, R

Angew. Chem. Int. Ed. Engl. 57(50), 16313-16317 (2018)

Self-assembly of a designed nucleoprotein architecture through multimodal interactions

Subramanian, R.H., Smith, S.J., Alberstein, R.G., Bailey, J.B., Zhang, L., Cardone, G., Suominen, L., Chami, M., Stahlberg, H., Baker, T.S., Tezcan, F.A.

ACS Central Science 4(11), 1578-1586 (2018)

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

Pérez Navarro, P., Genoud, C., Castano-Diez, D., Graff-Meyer, A., Lewis, A., de Gier, Y., Lauer, M.E., Britschgi, M., Bohrmann, B., Frank, S., Hench, J., Schweighauser, G., Rozemuller, A.J.M., van de Berg, W.D.J., Stahlberg, H., Shahmoradian, S.

Scientific Reports 8(18046), (2018)

Cryo-EM structures of a human ABCG2 mutant trapped in ATP-bound and substrate-bound states

Manolaridis, I., Jackson, S.M., Taylor, N., Kowal, J., Stahlberg, H., Locher, K.

Nature 563(7731), 426-430 (2018)

Phospholipid-block copolymer hybrid vesicles with lysosomal escape ability

Zong, W., Thingholm, B., Itel, F., Schattling, P.S., Brodszkij, E., Mayer, D., Stenger, S., Goldie, K., Han, X., Städler, B.

Langmuir 34(23), 6874-6886 (2018)

Protocols for Subtomogram Averaging of Membrane Proteins in the Dynamo Software Package

Pérez Navarro, P., Stahlberg, H., Castano-Diez, D.

Frontiers in Molecular Biosciences 5(82), 1-18 (2018)

Demonstration of femtosecond X-ray pump X-ray probe diffraction on protein crystals

Opara, N., Mohacsi, I., Makita, M., Castano-Diez, D., Diaz, A., Jurani, P., Marsh, M., Meents, A., Milne, C.J., Mozzanica, A., Padeste, C., Panneels, V., Sikorski, M., Song, S., Stahlberg, H., Vartiainen, I., Vera, L., Wang, M., Willmott, P.R., David, C.

Structural Dynamics 5(5), 054303 (2018)

An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel

Marchesi, A., Gao, X., Adaixo, R., Rheinberger, J., Stahlberg, H., Nimigean, C., Scheuring, S.

Nature Comm. 9(1), 3978 (2018)

Structure of a PSI–LHCI–cyt b6f supercomplex in Chlamydomonas reinhardtii promoting cyclic electron flow under anaerobic conditions

Steinbeck J., Ross, I.L., Rothnagel, R., Gäbelein, P., Schulze, S., Giles, N., Ali, R., Drysdale, R., Sierecki, E., Gambia, Y., Stahlberg, H., Takahashi, Y., Hippler, M., Hankamer, B.

PNAS 115(41), 10517-10522 (2018)

Cryo-EM structure of alpha-synuclein fibrils

Guerrero-Ferreira, R., Taylor, N., Mona, D., Ringler, P., Lauer, M.E., Riek, R., Britschgi, M., Stahlberg, H.

eLife 7(e36402), (2018)

Gold nanoparticles produced by laser ablation in water and in graphene oxide suspension

Torrisi, L., Cutroneo, M., Silipigni, L., Barreca, F., Fazio, B., Restuccia, N., Kovacik, L.

Philosphophical Magazine 98(24), 2205-2220 (2018)

Structural basis for regulation of human acetyl-CoA carboxylase

Hunkeler, M., Hagmann, A., Stuttfeld, E., Chami, M., Guri, Y., Stahlberg, H., Maier, T.

Nature 558, 470-474 (2018)

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

Jackson, S.M., Manolaridis, I., Kowal, J., Zechner, M., Taylor, N., Bause, M., Bauer, S., Bartholomaeus, R., Bernhardt, G., Koenig, B., Buschauer, A., Stahlberg, H., Altmann, K.H., Locher, K.P.

Nature Struct. Mol. Biol. 25(4), 333-340 (2018)

Image processing techniques for high-resolution structure determination from badly ordered 2D crystals

Biyani, N., Scherer, S., Righetto, R., Kowal, J., Chami, M., Stahlberg, H.

Journal of Structural Biology 203(2), 120-134 (2018)

Femtosecond X-ray coherent diffraction of aligned amyloid fibrils on low background graphene

Seuring, C., Ayyer, Filippaki, Barthelmess, Longchamp, Ringler, P., Pardini, Wojtas, Coleman, Dörner, Fuglerud, Hammarin, Habenstrein, Langkilde, Loquet, Meents, Riek, Stahlberg, H., Boutet, Hunter, Koglin, Liang, Ginn, Millane, Frank, Barty, Chapman

Nature Communications 9(1), 1836 (2018)

Miniaturized sample preparation for transmission electron microscopy

Schmidli, C., Rima, L., Arnold, S., Stohler, T., Syntychaki, A., Bieri, A., Albiez, S., Goldie, K., Chami, M., Stahlberg, H., Braun, T.

Journal of Visual Experiments (JOVE) (137), (2018)

3D correlative electron microscopy reveals continuity of Brucella-containing vacuoles with the endoplasmic reticulum

Sedzicki, J., Tschon, T., Huey-Low, S., Willemart, K., Goldie, K., Lewtesson, J.-J., Stahlberg, H., Dehio, C.

J. of Cell Science 131(4), (2018)

Cryo-EM reconstruction of Type VI secretion system baseplate and sheath distal end

Nazarov, S., Schneider, J.PO., Brackmann, M., Goldie, K., Stahlberg, H., Basler, M.

EMBO Journal 37, e97103 (2018)

Miniaturizing EM Sample Preparation: Opportunities, Challenges and "Visual Proteomics"

Arnold, S., Müller, S., Schmidli, C., Syntychaki, A., Rima, L., Chami, M., Stahlberg, H., Goldie, K., Braun, T.

Proteomics 18(5-6), e1700176 (2018)

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

Alam, A., Küng, R., Kowal, J., McLeod, R., Tremp, N., Broude, E.V., Roninson, I.B., Stahlberg, H., Locher, K.P.

PNAS 115(9), E1973-E1982 (2018)

MRCZ – A file format for cryo-TEM data with fast compression

McLeod, R., Righetto, R., Stewart, A., Stahlberg, H.

J. Struct. Biol. 201(3), 252-257 (2018)

High-resolution cryo-EM structure of the cyclic nucleotide-modulated potassium channel MloK1 in a lipid bilayer

Kowal, J., Biyani, N., Chami, M., Scherer, S., Rzepiela, A., Baumgartner, P., Upadhyay, V., Nimigean, C.N., Stahlberg, H.

Structure 26(1), 20-27 (2018)

The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats

Pasquali, C.C., Islam, Z., Adamoski, D., Monteze Ferreira, I., Righetto, R., Bettini, J., Portugal, R.V., Yue, W.W., Gonzalez, A., Gomes Dias, S.M., Berteli Ambrosio, A.L.

J. Biol. Chem. 292(27), 11572-11585 (2017)

Lipid Internal Dynamics Probed in Nanodiscs

Martinez, D., Decossas, M., Kowal, J., Frey, L., Stahlberg, H., Dufourc, E.-J.., Riek, R., Habenstein, B., Bibow, S., Loquet A.

ChemPhysChem 18(19), 2651-2657 (2017)

Expression, Biochemistry, and Stabilization with Camel Antibodies of Membrane Proteins: Case Study of the Mouse 5-HT3 Receptor

Hassaïne, G., Deluz, C., Grasso, L., Wyss, R., Hovius, R., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Peclinovska, L., Minniberger, S., Mebarki, L., Li, X.-D.., Vogel, H., Nury, H.

Methods Mol. Biol. 1635(Chapter 8), 139-168 (2017)

CryoEM structure of the extended type VI secretion system sheath–tube complex

Wang, J., Brackmann, M., Castano-Diez, D., Kudryashev, M., Goldie, K., Maier, T., Stahlberg, H., Basler, M.

Nature Microbiology 2(11), 1507-1512 (2017)

Three-Dimensional Imaging of Biological Tissue by Cryo X-Ray Ptychography

Shahmoradian, S., Tsai, E.H.R., Diaz, A., Guizar-Sicairos, M., Spycher, L., Raabe, J., Britschgi, M., Ruf, A., Stahlberg, H., Holler, M.

Scientific Reports 7(2), 6291 (2017)

Structure of the human multidrug transporter ABCG2

Taylor, N., Manolaridis, I., Jackson, S.M., Kowal, J., Stahlberg, H., Locher, K.P.

Nature 546, 504-509 (2017)

Membrane vesicle secretion and prophage induction in multidrug-resistant Stenotrophomonas maltophilia in response to ciprofloxacin stress

Devos, S., Van Putte, W., Vitse, J., Van Driessche, G., Stremersch, S., Van Den Broek, W., Raemdonck, K., Braeckmans, K., Stahlberg, H., Kudryashev, M., Savvides, S., Devreese, B.

Environmental Microbiology 19(10), 3930-3937 (2017)

Direct protein crystallization on ultrathin membranes for diffraction measurements at X-ray free electron lasers

Opara, N., Martiel, I., Arnold, S., Braun, T., Stahlberg, H., Makita, M., David, C., Padeste, C.

J. of Applied Crystallography 50, 909-918 (2017)

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Sejwal, K., Chami, M., Remigy, H., Vancraenenbroeck, R., Sibran, W., Sütterlin, R., Baumgartner, P., McLeod, R., Chartier-Harlin. M.-C., Baekelandt, V., Stahlberg, H., Taymans, J.-M.

Scientific Reports 7(1), 8667-8678 (2017)

Atomic structure of granulin determined from native nanocrystalline granulovirus using an X-ray free-electron laser

Gati, C., Oberthuer, D., Yefanov, O., Bunker, R.D., Stellato, F., Chiu, E., Yeh, S.M., Aquila, A., Basu, S., Bean, R., Beyerlein, K.R., Botha, S., Boutet, S., DePonte, D.P., Doak, R.B., Fromme, R., ..., Goldie, K., ..., Barty, A., Chapman, H.N.

Proc Natl Acad Sci U S A 114(9), 2247-2252 (2017)

Real-time Visualization of Phospholipid Degradation by Outer Membrane Phospholipase A using High-Speed Atomic Force Microscopy

Rangl M, Rima, L., Klement J, Miyagi A, Keller S, Scheuring S

J. Mol Biol. 429(7), 977-986 (2017)

Membrane association landscape of myelin basic protein portrays formation of the myelin major dense line

Raasakka, A., Ruskamo, S., Kowal, J., Barker, R., Baumann, A., Martel, A., Tuusa, J., Myllykoski, M., Bürck, J., Ulrich, A.S., Stahlberg, H., Kursula, P.

Scientific Reports 7(1), 4974-4991 (2017)

Direct visualization of glutamate transporter elevator mechanism by high-speed AFM

Ruan Y, Miyagi A, Wang X, Chami, M., Boudker O, Scheuring S,

Proc Natl Acad Sci USA 114(7), 1584-1588 (2017)

Focus: The interface between data collection and data processing in cryo-EM

Biyani, N., Righetto, R., McLeod, R., Caujolle-Bert, D., Castano-Diez, D., Goldie, K., Stahlberg, H.

J. Struct. Biol. 198(2), 124-133 (2017)

Cell-free reconstitution reveals centriole cartwheel assembly mechanisms

Guichard, P., Hamel, V., Le Quennec, M., Banterle, N., Iacovache, I., Nemcikova, V., Flückiger, I., Goldie, K., Stahlberg, H., Levy, D., Zuber, B., Gönczy, P.

Nature Communications 8:14813, (2017)

Structure of the Full-length VEGFR-1 Extracellular Domain in Complex with VEGF-A

Markovic-Mueller, S, Stuttfeld, E., Asthana, M., Weiner, T., Bliven, S., Goldie, K., Kisko, K., Capitani, G., Ballmer-Hofer, K.

Structure 25(2), 341-352 (2017)

Amyloid Fibril Polymorphism: Almost Identical on the Atomic Level, Mesoscopically Very Different

Seuring, C., Verasdonck, J., Ringler, P., Cadalbert, R., Stahlberg, H., Böckmann,A., Meier, B.H., Riek, R.

J. Phys. Chem. 121(8), 1783-1792 (2017)

Prepore Stability Controls Productive Folding of the BAM-independent Multimeric Outer Membrane Secretin PulD.

Guilvout I., Brier S., Chami, M., Hourdel V., Francetic O., Pugsley A.P., Chamot-Rooke J., Huysmans G.H.

J. Biol. Chem. 292(1), 328-338 (2017)

Blotting-free and lossless cryo-electron microscopy grid preparation from nanoliter-sized protein samples and single-cell extracts

Arnold, S., Albiez, S., Bieri, A., Syntychaki, A., Adaixo, R., McLeod, R., Goldie, K., Stahlberg, H., Braun, T.

J. Struct. Biol. (197), 220-226 (2017)

Proteoliposomes - a system to study membrane proteins under buffer gradients by cryo-EM

Sejwal, K., Chami, M., Baumgartner, P., Kowal, J., Müller, S., Stahlberg, H.

Nanotechnology Reviews 6(1), 57-74 (2017)

Solution structure of discoidal high-density lipoprotein particles with a shortened apolipoprotein A-I

Bibow,S., Polyhach, Y., Eichmann, C., Chi, C.N., Kowal, J., Albiez, S., McLeod, R., Stahlberg, H., Jeschke, G., Günter, P., Riek, R.

Nature Structural and Molecular Biology 24, 187-193 (2017)

Two-dimensional crystallization of the mouse serotonin 5-HT3A receptor

Rheinberger, J., Hassaine, G., Chami, M., Stahlberg, H., Vogel, H., Li, X.

Micron 90, 19-24 (2017)

Robust image alignment for cryogenic transmission electron microscopy

McLeod, R., Kowal, J., Ringler, P., Stahlberg, H.

J. Struct. Biol. 197(3), 279-293 (2017)

Thylakoid ultrastructure: Visualizing the photosynthetic machinery

Steinbeck, S., O’Mara, M.L., Ross, I., Stahlberg, H., Hankamer, B.

In: Hippler M. (eds) Chlamydomonas: Biotechnology and Biomedicine. Microbiology Monographs Vol. 31(Springer, Chambridge), 149-191 (2017)

Dynamo Catalogue: Geometrical tools and data management for particle picking in subtomogram averaging of cryo-electron tomograms

Castano-Diez, D., Kudryashev, M., Stahlberg, H.

J. Struct. Biol. 197(2), 135-144 (2017)

Evidence for a LOS and a capsular polysaccharide in Capnocytophaga canimorsus.

Renzi F, Ittig S, Sadovskaya I, Hess E, Lauber F, Dol M, Shin H, Mally M, Fiechter C, Sauder U, Chami, M., Cornelis G

Sci Rep. 6(Article number: 38914), (2016)

DNA-Mediated Self-Organization of Polymeric Nanocompartments Leads to Interconnected Artificial Organelles.

Liu J, Postupalenko V, Lörcher S, Wu D, Chami, M., Meier W, Palivan CG.

Epub 16(11), 7128-7136 (2016)

Specific Binding of Cu(II) Ions to Amyloid-Beta Peptides Bound to Aggregation-Inhibiting Molecules or SDS Micelles Creates Complexes that Generate Radical Oxygen Species.

Tiiman A, Luo J, Wallin C, Olsson L, Lindgren J, Jarvet J, Per R, Sholts SB, Rahimipour S, Abrahams, J., Karlström AE, Gräslund A, Wärmländer SK

J Alzheimers Dis. 54(3), 971-982 (2016)

Assembling of the Mycobacterium tuberculosis Cell Wall Core.

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J Biol Chem. 291(26), 18867-79 (2016)

Biochemical and biophysical approaches to study the structure and function of the chloride channel (ClC) family of proteins

Abeyrathne, P., Chami, M., Stahlberg, H.

Biochimie 128-129, 154-162 (2016)

Investigation of the thin film crystallization of a DNA copolymer hybrid composed of chitosan.

Ilyès Safir, Chami, M., Thomas Buergi, Corinne Nardin

Polymer International 65(10), 1165-1171 (2016)

Gold Nanowire Fabrication with Surface-Attached Lipid Nanotube Templates.

Jajcevic K., Chami, M., Sugihara K.

Small 12(35), 4830-4836 (2016)

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

Sborgi, L., Rühl, S., Mulvihill, E., Pipercevic, J., Heilig, R., Stahlberg, H., Farad, C.J., Müller, D.J., Broz, P., Hiller, S.

EMBO Journal 35(16), 1766-1778 (2016)

Real-time visualization of conformational changes within single MloK1 cyclic nucleotide-modulated channels

Rangl, M., Miyagi, A., Kowal, J., Stahlberg, H., Nimigean, C., Scheuring, S.

Nature Communications 7, 12789 (2016)

Cross-interactions between the Alzheimer Disease Amyloid-β Peptide and Other Amyloid Proteins: A Further Aspect of the Amyloid Cascade Hypothesis.

Luo J, Wärmländer S, Gräslund A, Abrahams, J.

J Biol Chem. 291(32), 16485-93 (2016)

Chaperonin–Dendrimer Conjugates for siRNA Delivery

Martin G. Nussbaumer, Jason T. Duskey, Martin Rother, Kasper Renggli, Chami, M., Nico Bruns

Advanced Science 133(12), 4476-4483 (2016)

Structural basis for haem piracy from host haemopexin by Haemophilus influenzae.

Zambolin S., Clantin B., Chami, M., Hoos S., Haouz A., Villeret V., Delepelaire P.

Nature Comm. 7(11590), (2016)

Patent: Cryo-electron microscopy from nanoliter sample volumes

Arnold, S., Stahlberg, H., Braun, T.

UniTecTra Technology Opportunity, Ref. No. UA-17/141 (patent application filed), (2016)

Total sample conditioning and preparation of nanoliter volumes for electron microscopy

Arnold, S., Albiez, S., Opara, N., Chami, M., Schmidli, C., Bieri, A., Padeste, C., Stahlberg, H., Braun, T.

ACS Nano 10, 4981-4988 (2016)

Characterization of mAb dimers reveals predominant dimer forms common in therapeutic mAbs

Plath, F., Ringler, P., Graff, A., Stahlberg, H., Lauer, M., Rufer, A., Graewert, M., Svergun, D., Kellermann, G., Winkler, C., Stücke, J.O., Koulov, A., Schnaible, V.

mAbs 8(5), 928-940 (2016)

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer's disease.

Wallin C, Kulkarni Y, Abelein A, Jarvet J, Liao Q, Strodel B, Olsson L, Luo J, Abrahams, J., Sholts S, Roos P, Kamerlin S, Gräslund A, Wärmländer S

J Trace Elem Med Biol. 2016 Dec(38), 183-193 (2016)

Cullin-RING ubiquitin E3 ligase regulation by the COP9 signalosome

Cavadini, S., Fischer, E.S., Goldie, K., Boehm, K., Lingaraju, G.M., Jones, M., Bunker, R.D., Richkule, R., Pantelic, R., Mohamed, W.I., Hassiepen, U., Beckwith, R.E.J., Stahlberg, H., and Thomae, N.H.

Nature 531(7596), 598-603 (2016)

Atomic structure of bacteriophage T4 baseplate and its function in triggering sheath contraction

Taylor, N., Prokhorov, N.S., Guerrero-Ferreira, R.C., Shneider, M.M., Browning, C., Goldie, K., Stahlberg, H., Leiman, P.G.

Nature 533(7603), 346-352 (2016)

Principles governing the self-assembly of coiled-coil protein nanoparticles

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Biophys J 110(3), 646-660 (2016)

Cholesteryl ester transfer between lipoproteins does not require the formation of a ternary tunnel complex with the cholesteryl ester transfer protein

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J. Struct. Biol. 194(2), 191-198 (2016)

Preparation and characterization of stable alpha-synuclein lipoprotein particles

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J. Biol. Chem. 291(16), 8516-8527 (2016)

The structure of the mouse serotonin 5-HT3 receptor in lipid vesicles

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Structure 24(1), 165-170 (2016)

The lipidome associated with the gamma-secretase complex is required for its integrity and activity.

Ayciriex, S., Gerber, H., Osuna, G.M., Chami, M., Stahlberg, H., Shevchenko, A., Fraering, P.C.

Biochemical Journal 473(3), 321-334 (2016)

Glasslike Membrane Protein Diffusion in a Crowded Membrane.

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ACS Nano 10(2), 2584-90 (2016)

Automated high-throughput viscosity and density sensor using nanomechanical resonators

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Reciprocal Molecular Interactions between the Aβ Peptide Linked to Alzheimer’s Disease and Insulin Linked to Diabetes Mellitus Type II

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ACS Chem. Neurosci. 7(3), 269–274 (2016)

Ab initio structure determination of nanocrystals of organic pharmaceutical compounds by electron diffraction at room temperature using a Timepix quantum area direct electron detector

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Acta Cryst. A72, 236-242 (2016)

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Very high-density lipoprotein and vitellin as carriers of novel biliverdins IXalpha with a farnesyl side-chain presumably derived from heme A in Spodoptera littoralis

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On-chip lysis of mammalian cells through a handheld corona device

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Optimizing the design of protein nanoparticles as carriers for vaccine applications

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Phospholipid-polymer amphiphile hybrid assemblies and their interaction with macrophages

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A posteriori correction of camera characteristics from large image data sets

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Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

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Proc Natl Acad Sci U S A 112(43), 13237-42 (2015)

Structure of the type VI secretion system contractile sheath

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Diaminopimelic acid amidation in corynebacteriales: new insights into the role of LtsA in peptidoglycan modification

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J Biol Chem 290(21), 13079-94 (2015)

Translational arrest by a prokaryotic signal recognition particle is mediated by RNA interactions

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Yersinia enterocolitica type III secretion injectisomes form regularly spaced clusters, which incorporate new machines upon activation

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Mol Microbiol 95(5), 875-84 (2015)

Lipids assist the membrane insertion of a BAM-independent outer membrane protein

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Influence of squeeze-film damping on higher-mode microcantilever vibrations in liquid

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Reduced synaptic activity in neuronal networks derived from embryonic stem cells of murine Rett syndrome model

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Rendering graphene supports hydrophilic with non-covalent aromatic functionalization for transmission electron microscopy

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Non-chaperone proteins can inhibit aggregation and cytotoxicity of Alzheimer amyloid beta peptide

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2dx_automator: implementation of a semiautomatic high-throughput high-resolution cryo-electron crystallography pipeline

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BMC Bioinformatics 15, 84 (2014)

3D cryo-electron reconstruction of BmrA, a bacterial multidrug ABC transporter in an inward-facing conformation and in a lipidic environment

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pH-responsive PDMS-b-PDMAEMA micelles for intracellular anticancer drug delivery

Car, A., Baumann, P., Duskey, J. T., Chami, M., Bruns, N., Meier, W.

Biomacromolecules 15(9), 3235-45 (2014)

A KcsA/MloK1 chimeric ion channel has lipid-dependent ligand-binding energetics

McCoy, J. G., Rusinova, R., Kim, D. M., Kowal, J., Banerjee, S., Jaramillo Cartagena, A., Thompson, A. N., Kolmakova-Partensky, L., Stahlberg, H., Andersen, O. S., Nimigean, C. M.

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Poly(N-isopropylacrylamide)/poly(dopamine) capsules

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Langmuir 30(19), 5592-8 (2014)

Alzheimer peptides aggregate into transient nanoglobules that nucleate fibrils

Luo, J., Warmlander, S. K., Graslund, A., Abrahams, J.

Biochemistry 53(40), 6302-8 (2014)

Single particle 3D reconstruction for 2D crystal images of membrane proteins

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Bacterial secretins form constitutively open pores akin to general porins

Disconzi, E., Guilvout, I., Chami, M., Masi, M., Huysmans, G. H., Pugsley, A. P., Bayan, N.

J Bacteriol 196(1), 121-8 (2014)

Structural and mechanistic paradigm of leptin receptor activation revealed by complexes with wild-type and antagonist leptins

Moharana, K., Zabeau, L., Peelman, F., Ringler, P., Stahlberg, H., Tavernier, J., Savvides, S. N.

Structure 22(6), 866-77 (2014)

Carbon nanotube growth on AlN support: comparison between Ni and Fe chemical states and morphology

Eren, B., Marot, L., Steiner, R., de los Arcos, T., Duggelin, M., Mathys, D., Goldie, K., Olivieri, V., Meyer, E.

Chem Phys Lett 609, 82-87 (2014)

Clostridium difficult toxin CDT hijacks microtubule organization and reroutes vesicle traffic to increase pathogen adherence

Schwan, C., Kruppke, A. S., Nolke, T., Schumacher, L., Koch-Nolte, F., Kudryashev, M., Stahlberg, H., Aktories, K.

Proc Natl Acad Sci U S A 111(6), 2313-8 (2014)

Confined multiple enzymatic (cascade) reactions within poly(dopamine)-based capsosomes

Hosta-Rigau, L., York-Duran, M. J., Zhang, Y., Goldie, K., Stadler, B.

ACS Appl Mater Interfaces 6(15), 12771-9 (2014)

Review: Cryo-electron microscopy of membrane proteins

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Synthesis of anisotropic, amphiphilic grafted multi-star polymers and investigation of their self-assembling characteristics

Blencowe, A., Tan, J. F., Goh, T. K., Goldie, K., Zhang, X. H., Qiao, G. G.

Aust J Chem 67(1), 49-58 (2014)

The Aβ peptide forms non-amyloid fibrils in the presence of carbon nanotubes

Luo, J. H., Warmlander, S. K. , Yu, C. H., Muhammad, K., Graslund, A., Abrahams, J.

Nanoscale 6(12), 6720-6726 (2014)

The amine content of PEGylated chitosan Bombyx mori nanoparticles acts as a trigger for protein delivery

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Langmuir 30(4), 965-75 (2014)

Cyclic peptides as inhibitors of amyloid fibrillation

Luo, J., Abrahams, J.

Chemistry 20(9), 2410-9 (2014)

Development of amphiphilic multi-star polymers with highly grafted pyrene connectors as unimolecular encapsulation devices

Blencowe, A., Tan, J. F., Goh, T. K., Goldie, K., Qiao, G. G.

Polymer Chemistry 5(5), 1682-1692 (2014)

Development of high-temperature strain instrumentation for in situ SEM evaluation of ductility dip cracking

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J Microsc 254(3), 157-65 (2014)

The hairpin conformation of the amyloid beta peptide is an important structural motif along the aggregation pathway

Abelein, A., Abrahams, J., Danielsson, J., Graslund, A., Jarvet, J., Luo, J. H., Tiiman, A., Warmlander, S. K.

J Biol Inorg Chem 19(42099), 623-634 (2014)

Disease modeling and phenotypic drug screening for diabetic cardiomyopathy using human induced pluripotent stem cells

Drawnel, F. M., Boccardo, S., Prummer, M., Delobel, F., Graff, A., Weber, M., Gerard, R., Badi, L., Kam-Thong, T., Bu, L., Jiang, X., Hoflack, J. C., Kiialainen, A., Jeworutzki, E., Aoyama, N., Carlson, C., Burcin, M., Gromo, G., Boehringer, M., Stahlberg, H., Hall, B. J., Magnone, M. C., Kolaj

Cell Rep 9(3), 810-21 (2014)

Endogenous polyamines reduce the toxicity of soluble abeta peptide aggregates associated with Alzheimer's disease

Luo, J., Mohammed, I., Warmlander, S. K., Hiruma, Y., Graslund, A., Abrahams, J.

Biomacromolecules 15(6), 1985-91 (2014)

The ultrastructure of Chlorobaculum tedium revealed by cryo-electron tomography

Kudryashev, M., Aktoudianaki, A., Dedoglou, D., Stahlberg, H., Tsiotis, G.

Biochim Biophys Acta 1837(10), 1635-42 (2014)

Exploring the interactome: microfluidic isolation of proteins and interacting partners for quantitative analysis by electron microscopy

Giss, D., Kemmerling, S., Dandey, V., Stahlberg, H., Braun, T.

Anal Chem 86(10), 4680-7 (2014)

Functional surface engineering by nucleotide-modulated potassium channel insertion into polymer membranes attached to solid supports

Kowal, J.L., Kowal, J., Wu, D., Stahlberg, H., Palivan, C. G., Meier, W. P.

Biomaterials 35(26), 7286-94 (2014)

X-ray structure of the mouse serotonin 5-HT3 receptor

Hassaine, G., Deluz, C., Grasso, L., Wyss, R., Tol, M. B., Hovius, R., Graff, A., Stahlberg, H., Tomizaki, T., Desmyter, A., Moreau, C., Li, X. D., Poitevin, F., Vogel, H., Nury, H.

Nature 512(7514), 276-81 (2014)

Independent domain assembly in a trapped folding intermediate of multimeric outer membrane secretins

Guilvout, I., Chami, M., Disconzi, E., Bayan, N., Pugsley, A. P., Huysmans, G. H.

Structure 22(4), 582-9 (2014)

Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components

Zivanovic, Y., Confalonieri, F., Ponchon, L., Lurz, R., Chami, M., Flayhan, A., Renouard, M., Huet, A., Decottignies, P., Davidson, A. R., Breyton, C., Boulanger, P.

J Virol 88(2), 1162-74 (2014)

Label-free, optical sensing of the supramolecular assembly into fibrils of a ditryptophan-DNA hybrid

Gour, N., Abraham, J. N., Chami, M., Castillo, A., Verma, S., Vebert-Nardin, C.

Chem Commun (Camb) 50(52), 6863-5 (2014)

Ligand-induced structural changes in the cyclic nucleotide-modulated potassium channel MloK1

Kowal, J., Chami, M., Baumgartner, P., Arheit, M., Chiu, P. L., Rangl, M., Scheuring, S., Schroder, G. F., Nimigean, C. M., Stahlberg, H.

Nat Commun 5, 3106 (2014)

Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1

Franke, B., Gasch, A., Rodriguez, D., Chami, M., Khan, M. M., Rudolf, R., Bibby, J., Hanashima, A., Bogomolovas, J., von Castelmur, E., Rigden, D. J., Uson, I., Labeit, S., Mayans, O.

Open Biol 4, 130172 (2014)

Microfluidics to isolate untagged proteins from cell extracts for visual analysis by electron microscopy

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A tumorigenic actin mutant alters fibroblast morphology and multicellular assembly properties

Blache U., Silván U., Plodinec M., Sütterlin, R., Jakob R., Klebba I., Bentires-Alj M., Aebi U., Schoenenberger CA.

Cytoskeleton (Hoboken) 70(10), 635-650 (2013)

Real-time viscosity and mass density sensors requiring microliter sample volume based on nanomechanical resonators

Bircher BA., Duempelmann L., Renggli K., Lang HP., Gerber C.K., Bruns N., Braun, T.

Anal Chem. 85(18), 8676-83 (2013)

Photothermal excitation of microcantilevers in liquid: effect of the excitation laser position on temperature and vibrational amplitude

Bircher B.A., Duempelmann L., Lang H.-P., Gerber C., Braun, T.

Micro & Nano Letters 8(11), 770-4 (2013)

Poly(vinyl alcohol) physical hydrogel nanoparticles, not polymer solutions, exert inhibition of nitric oxide synthesis in cultured macrophages

Andreasen, S. O., Chong, S. F., Wohl, B. M., Goldie, K., Zelikin, A. N.

Biomacromolecules 14(5), 1687-95 (2013)

A Medipix quantum area detector allows rotation electron diffraction data collection from submicrometre three-dimensional protein crystals

Nederlof, I., van Genderen, E., Li, Y. W., Abrahams, J.

Acta Crystallogr D Biol Crystallogr 69(Pt 7), 1223-30 (2013)

An efficient nanolitre-volume multi-channel device for highly viscous materials used in membrane protein crystallization

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J Appl Crystallogr 46, 829-831 (2013)

Assessing the conformational changes of pb5, the receptor-binding protein of phage T5, upon binding to its Escherichia coli receptor FhuA

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J Biol Chem 288(42), 30763-72 (2013)

Single-cell lysis for visual analysis by electron microscopy

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J Struct Biol 183(3), 467-73 (2013)

Assessment of a nanocrystal 3-D morphology by the analysis of single HAADF-HRSTEM images

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Nanoscale Res Lett 8(1), 475 (2013)

Atomic structure and hierarchical assembly of a cross-beta amyloid fibril

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Automation of image processing in electron crystallography

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Structural and mechanistic insights into VEGF receptor 3 ligand binding and activation

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Proc Natl Acad Sci U S A 110(32), 12960-5 (2013)

Capture of unstable protein complex on the streptavidin-coated single-walled carbon nanotubes

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J Nanopart Res 15(4), (2013)

Cellular polyamines promote amyloid-beta (Abeta) peptide fibrillation and modulate the aggregation pathways

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ACS Chem Neurosci 4(3), 454-62 (2013)

Structure and substrate-induced conformational changes of the secondary citrate/sodium symporter CitS revealed by electron crystallography

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Structure 21(7), 1243-50 (2013)

Structure of the dodecameric Yersinia enterocolitica secretin YscC and its trypsin-resistant core

Kowal, J., Chami, M., Ringler, P., Müller, S., Kudryashev, M., Castano-Diez, D., Amstutz, M., Cornelis, G. R., Stahlberg, H., Engel, A.

Structure 21(12), 2152-61 (2013)

Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast

Lemgruber, L., Kudryashev, M., Dekiwadia, C., Riglar, D. T., Baum, J., Stahlberg, H., Ralph, S. A., Frischknecht, F.

Malar J 12, 25 (2013)

The rhodopsin-transducin complex houses two distinct rhodopsin molecules

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Thermal unfolding of a mammalian pentameric ligand-gated ion channel proceeds at consecutive, distinct steps

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J Biol Chem 288(8), 5756-69 (2013)

Human lysozyme inhibits the in vitro aggregation of Abeta peptides, which in vivo are associated with Alzheimer's disease

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Image processing of 2D crystal images

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Biocompatible functionalization of polymersome surfaces: a new approach to surface immobilization and cell targeting using polymersomes

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Sensing surface PEGylation with microcantilevers

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A deficiency in arabinogalactan biosynthesis affects Corynebacterium glutamicum mycolate outer membrane stability

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A graphene oxide center dot streptavidin complex for biorecognition - towards affinity purification

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An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: importance of formulation

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Structural characterization of the rod cGMP phosphodiesterase 6

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Bipartite design of a self-fibrillating protein copolymer with nanopatterned peptide display capabilities

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Unit-cell determination from randomly oriented electron-diffraction patterns

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Acta Crystallogr D Biol Crystallogr 65(Pt 7), 625-32 (2009)

Involvement of a carboxylated lysine in UV damage endonuclease

Meulenbroek, E. M., Paspaleva, K., Thomassen, E. A. J., Abrahams, J., Goosen, N., Pannu, N. S.

Protein Sci 18(3), 549-558 (2009)

Isolation and characterization of low nucleic acid (LNA)-content bacteria

Wang, Y., Hammes, F., Boon, N., Chami, M., Egli, T.

ISME J 3(8), 889-902 (2009)

Isolation, characterisation and molecular imaging of a high-molecular-weight insect biliprotein, a member of the hexameric arylphorin protein family

Kayser, Hartmut, Mann, Karlheinz, Machaidze, Gia, Nimtz, Manfred, Ringler, P., Müller, S., Aebi, U.

J Mol Biol 389(1), 74-89 (2009)

Mammalian Navigators are microtubule plus-end tracking proteins that can reorganize the cytoskeleton to induce neurite-like extensions

van Haren, J., Draegestein, K., Keijzer, N., Abrahams, J., Grosveld, F., Peeters, P. J., Moechars, D., Galjart, N.

Cell Motil Cytoskeleton 66(10), 824-38 (2009)

MASDET - a fast and user-friendly multiplatform software for mass determination by dark-field electron microscopy

Krzyvanek, Vladislav, Müller, S., Engel, Andreas , Reichelt, Rudolf

J Struct Biol 165(2), 78 - 87 (2009)

Medipix 2 detector applied to low energy electron microscopy

van Gastel, R., Sikharulidze, I., Schramm, S., Abrahams, J., Poelsema, B., Tromp, R. M., van der Molen, S. J.

Ultramicroscopy 110(1), 33-5 (2009)

Membrane activity of a C-reactive protein

Harrington, J. M., Chou, H. T., Gutsmann, T., Gelhaus, C., Stahlberg, H., Leippe, M., Armstrong, P. B.

FEBS Lett 583(6), 1001-5 (2009)

Molecular architecture of Streptococcus pneumoniae TIGR4 pili

Hilleringmann, M., Ringler, P., Müller, S., De Angelis, G., Rappuoli, R., Ferlenghi, I., Engel, A.

EMBO J 28(24), 3921-30 (2009)

Multi-parameter microcantilever sensor for comprehensive characterization of Newtonian fluids

Ghatkesar, M. K., Rakhmatullina, E., Lang, H. P., Gerber, Ch., Hegner, M., Braun, T.

Sensor Actuat B-Chem 135(1), 133-138 (2008)

Structure determination using electron crystallography

Evans, J.E., Renault, L., Stahlberg, H.

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Comprehensive characterization of molecular interactions based on nanomechanics

Ghatkesar MK, Lang HP, Gerber C, Hegner M, Braun, T.

PLoS ONE 3(11), e3610 (2008)

2dx - Automated 3D structure reconstruction from 2D crystal data

Gipspon, B., Zeng, X., Stahlberg, H.

Microscopy and Microanalysis 14(Supp 2), 1290-1291 (2008)

Resonating modes of vibrating microcantilevers in liquid

Ghatkesar, M. K., Braun, T., Barwich, V., Ramseyer, J.-P., Gerber, C., Hegner, M., H.P. Lang

Appl Phys Lett 92, 3106 (2008)

Omp85(Tt) from Thermus thermopiles HB27: an ancestral type of the Omp85 protein family

Nesper, J., Brosig, A., Ringler, P., Patel, G. J., Müller, S., Kleinschmidt, J. H., Boos, W., Diederichs, K., Welte, W.

J Bacteriol 190(13), 4568-75 (2008)

Phage T5 straight tail fiber is a multifunctional protein acting as a tape measure and carrying fusogenic and muralytic activities

Boulanger, P., Jacquot, P., Plancon, L., Chami, M., Engel, A., Parquet, C., Herbeuval, C., Letellier, L.

J Biol Chem 283(20), 13556-64 (2008)

Projection structure of a member of the amino acid/polyamine/organocation transporter superfamily

Casagrande, F., Ratera, M., Schenk, A. D., Chami, M., Valencia, E., Lopez, J. M., Torrents, D., Engel, A., Palacin, M., Fotiadis, D.

J Biol Chem 283(48), 33240-8 (2008)

Artificial binding proteins (Affitins) as probes for conformational changes in secretin PulD

Krehenbrink, M., Chami, M., Guilvout, I., Alzari, P. M., Pecorari, F., Pugsley, A. P.

J Mol Biol 383(5), 1058-68 (2008)

Atomic models of de novo designed ccbeta-met amyloid-like fibrils

Steinmetz, M. O., Gattin, Z., Verel, R., Ciani, B., Stromer, T., Green, J. M., Tittmann, P., Schulze-Briese, C., Gross, H., van Gunsteren, W. F., Meier, B. H., Serpell, L. C., Müller, S., Kammerer, R. A.

J Mol Biol 376(3), 898-912 (2008)

Biological scanning transmission electron microscopy

Müller, S., Engel, A

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Structural properties of AMP-activated protein kinase: dimerization, molecular shape, and changes upon ligand binding

Riek, U., Scholz, R., Konarev, P., Rufer, A., Suter, M., Nazabal, A., Ringler, P., Chami, M., Müller, S., Neumann, D., Forstner, M., Hennig, M., Zenobi, R., Engel, A., Svergun, D., Schlattner, U., Wallimann, T.

J Biol Chem 283(26), 18331-43 (2008)

Bridging across length scales: multi-scale ordering of supported lipid bilayers via lipoprotein self-assembly and surface patterning

Vinchurkar, M. S., Bricarello, D. A., Lagerstedt, J. O., Buban, J. P., Stahlberg, H., Oda, M. N., Voss, J. C., Parikh, A. N.

J Am Chem Soc 130(33), 11164-9 (2008)

Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of chlorite dismutase: a detoxifying enzyme producing molecular oxygen

de Geus, D. C., Thomassen, E. A. J., van der Feltz, C. L., Abrahams, J.

Acta Crystallogr Sect F Struct Biol Cryst Commun 64, 730-732 (2008)

Conductive supports for combined AFM-SECM on biological membranes

Frederix, P. L., Bosshart, P. D., Akiyama, T., Chami, M., Gullo, M. R., Blackstock, J. J., Dooleweerdt, K., de Rooij, N. F., Staufer, U., Engel, A.

Nanotechnology 19(38), 384004 (2008)

The fold of alpha-synuclein fibrils

Vilar, M., Chou, H. T., Luhrs, T., Maji, S. K., Riek-Loher, D., Verel, R., Manning, G., Stahlberg, H., Riek, R.

Proc Natl Acad Sci U S A 105(25), 8637-42 (2008)

Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state

Zuber, B., Chami, M., Houssin, C., Dubochet, J., Griffiths, G., Daffe, M.

J Bacteriol 190(16), 5672-80 (2008)

The Moraxella IgD-binding protein MID/Hag is an oligomeric autotransporter

Hallström, T., Müller, S., Mörgelin, M., Möllenkvist, A., Forsgren, A., Riesbeck, K.

Microbes Infect 10(4), 374-381 (2008)

Unravelling the structure of the lamellipodium

Small, J. V., Auinger, S., Nemethova, M., Koestler, S., Goldie, K., Hoenger, A., Resch, G. P.

J Microsc 231(3), 479-85 (2008)

Vacuolar protein sorting: two different functional states of the AAA-ATPase Vps4p

Hartmann, C., Chami, M., Zachariae, U., de Groot, B. L., Engel, A., Grütter, M. G.

J Mol Biol 377(2), 352-63 (2008)

What transmission electron microscopes can visualize now and in the future

Müller, S., Aebi, U., Engel, A.

J Struct Biol 163(3), 235-245 (2008)

In vitro multimerization and membrane insertion of bacterial outer membrane secretin PulD

Guilvout, I., Chami, M., Berrier, C., Ghazi, A., Engel, A., Pugsley, A. P., Bayan, N.

J Mol Biol 382(1), 13-23 (2008)

Low-dose aberration corrected cryo-electron microscopy of organic specimens

Evans, J. E., Hetherington, C., Kirkland, A., Chang, L. Y., Stahlberg, H., Browning, N.

Ultramicroscopy 108(12), 1636-44 (2008)

Membrane pore formation by pentraxin proteins from Limulus, the American horseshoe crab

Harrington, J. M., Chou, H. T., Gutsmann, T., Gelhaus, C., Stahlberg, H., Leippe, M., Armstrong, P. B.

Biochem J 413(2), 305-13 (2008)

Microtubule plus-end conformations and dynamics in the periphery of interphase mouse fibroblasts

Zovko, S., Abrahams, J., Koster, A. J., Galjart, N., Mommaas, A. M.

Mol Biol Cell 19(7), 3138-46 (2008)

Molecular electron microscopy: state of the art and current challenges

Stahlberg, H., Walz, T.

ACS Chem Biol 3(5), 268-81 (2008)

2dx_merge: data management and merging for 2D crystal images

Gipson, B., Zeng, X., Stahlberg, H.

J. Struct. Biol. 160(3), 375-384 (2007)

Editorial: Spotlight on Electron Crystallography

Hankamer, B., Glaeser, B., Stahlberg, H.

J Struct Biol 160(3), 263-264 (2007)

Three-dimensional electron microscopy of macromolecular assemblies (J. Frank), Book Review

Renault, L., Stahlberg, H.

Scanning 29(1), 37 (2007)

Capacitive micromachined ultrasonic transducers for chemical detection in nitrogen

Park, K., Lee, H., Yaralioglu, G., Ergun, A., Oralkan, O., Kupnik, M., Quate, C., Khuri-Yakub, B., Braun, T., Ramseyer, J.P., Lang, H.P., Hegner, M., J.K. Gimzewski

Appl Phys Lett 91(9), 094102 (2007)

Digital Processing of Multi-Mode Nano-Mechanical Cantilever Data

Braun, T., Ghatkesar, M. K., Barwich, V., Huber, N., Nugaeva, W., Lang, H.P., Ramseyer, J.P., Gerber, Ch., M. Hegner

Journal of Physics International Conference on Nanoscience and Technology(61), 341-345 (2007)

Functionalization of gold and silicon surfaces by copolymer brushes using surface-initiated ATRP

Rakhmatullina, E., Braun, T., Kaufmann, T., Spillmann, H., Malinova, V., W. Meier.

Macromol Chem Physic 208(12), 1283–1293 (2007)

Processing of kinetic microarray signals

Braun, T., Huber, F., Ghatkesar, M. K., Backmann, N., Lang, H.-P., Gerber, C., M. Hegner

Sensor Actuat B-Chem 128, 75-82 (2007)

Higher modes of vibration increase mass sensitivity in nanomechanical microcantilevers

Ghatkesar, M. K., Barwich, V., Braun, T., Ramseyer, J.-P., Gerber, C., Hegner, M. et al.

Nanotechnology 18(44), (2007)

Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution

Runge, K. E., Evans, J. E., He, Z. Y., Gupta, S., McDonald, K. L., Stahlberg, H., Primakoff, P., Myles, D. G.

Dev Biol 304(1), 317-25 (2007)

2dx – User-friendly image processing for 2D crystals

Gipson, B., Zeng, X., Zhang, Z. Y., Stahlberg, H.

J Struct Biol 157(1), 64-72 (2007)

A maximum likelihood approach to two-dimensional crystals

Zeng, X., Stahlberg, H., Grigorieff, N.

J Struct Biol 160(3), 362-74 (2007)

Projection maps of three members of the KdgM outer membrane protein family

Signorell, G. A., Chami, M., Condemine, G., Schenk, A. D., Philippsen, A., Engel, A., Remigy, H. W.

J Struct Biol 160(3), 395-403 (2007)

Reprint of "Structural and mechanistic aspects of Amt/Rh proteins" [J. Struct. Biol. 158 (2007) 472-481]

Javelle, A., Lupo, D., Li, X. D., Merrick, M., Chami, M., Ripoche, P., Winkler, F. K.

J Struct Biol 159(2), 243-52 (2007)

Self-organization behavior of methacrylate-based amphiphilic di- and triblock copolymers

Rakhmatullina, E., Braun, T., Chami, M., Malinova, V., Meier, W.

Langmuir 23(24), 12371-9 (2007)

Automatic lattice determination for two-dimensional crystal images

Zeng, X., Gipson, B., Zheng, Z. Y., Renault, L., Stahlberg, H.

J Struct Biol 160(3), 353-61 (2007)

Structural analysis of vimentin and keratin intermediate filaments by cryo-electron tomography

Norlen, L., Masich, S., Goldie, K., Hoenger, A.

Exp Cell Res 313(10), 2217-27 (2007)

Structural and kinetic studies of induced fit in xylulose kinase from Escherichia coli

Di Luccio, E., Petschacher, B., Voegtli, J., Chou, H. T., Stahlberg, H., Nidetzky, B., Wilson, D. K.

J Mol Biol 365(3), 783-98 (2007)

Structural and mechanistic aspects of Amt/Rh proteins

Javelle, A., Lupo, D., Li, X. D., Merrick, M., Chami, M., Ripoche, P., Winkler, F. K.

J Struct Biol 158(3), 472-81 (2007)

Crystal structure of the DNA repair enzyme ultraviolet damage endonuclease

Paspaleva, K., Thomassen, E., Pannu, N. S., Lwai, S., Moolenaar, G. F., Goosen, N., Abrahams, J.

Structure 15(10), 1316-1324 (2007)

Cyclops: new modular software suite for cryo-EM

Plaisier, J. R., Jiang, L., Abrahams, J.

J Struct Biol 157(1), 19-27 (2007)

Dissecting the 3-D structure of vimentin intermediate filaments by cryo-electron tomography

Goldie, K., Wedig, T., Mitra, A. K., Aebi, U., Herrmann, H., Hoenger, A.

J Struct Biol 158(3), 378-85 (2007)

Electron crystallography of membrane proteins

Chou, H. T., Evans, J. E., Stahlberg, H.

Methods Mol Biol 369, 331-43 (2007)

Epidemiologic characteristics of catastrophic musculoskeletal injuries in thoroughbred racehorses

Cruz, A. M., Poljak, Z., Filejski, C., Lowerison, M. L., Goldie, K., Martin, S. W., Hurtig, M. B.

Am J Vet Res 68(12), 1370-5 (2007)

The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution

Chiu, P. L., Pagel, M. D., Evans, J., Chou, H. T., Zeng, X., Gipson, B., Stahlberg, H., Nimigean, C. M.

Structure 15(9), 1053-64 (2007)

Function and molecular architecture of the Yersinia injectisome tip complex

Broz, Petr, Müller, Catherine A., Müller, S., Philippsen, Ansgar, Sorg, Isabel, Engel, A., Cornelis, Guy R.

Molec Microbiol 65(5), 1311-1320 (2007)

Heterogeneous nucleation of three-dimensional protein nanocrystals

Georgieva, D. G., Kuil, M. E., Oosterkamp, T. H., Zandbergen, H. W., Abrahams, J.

Acta Crystallogr D Biol Crystallogr 63(Pt 5), 564-70 (2007)

Visualization of cell microtubules in their native state

Bouchet-Marquis, C., Zuber, B., Glynn, A. M., Eltsov, M., Grabenbauer, M., Goldie, K., Thomas, D., Frangakis, A. S., Dubochet, J., Chretien, D.

Biol Cell 99(1), 45-53 (2007)

YaeT-independent multimerization and outer membrane association of secretin PulD

Collin, S., Guilvout, I., Chami, M., Pugsley, A. P.

Mol Microbiol 64(5), 1350-7 (2007)

YscU recognizes translocators as export substrates of the Yersinia injectisome

Sorg, Isabel, Wagner, Stefanie, Amstutz, Marlise, Müller, S., Broz, Petr, Lussi, Yvonne, Engel, A., Cornelis, Guy R.

EMBO J 26(12), 3015-3024 (2007)

Malingering on the Social Security disability consultative exam: a new rating scale

Chafetz, M. D., Abrahams, J., Kohlmaier, J.

Arch Clin Neuropsychol 22(1), 42018 (2007)

Avoiding charge induced drift in vitrified biological specimens through scanning transmission electron microscopy.

Nicotra, G., Chou, H.-T., Stahlberg, H., Browning, N.D.

Microscopy and Microanalysis 12(Supp. 02), 246-247 (2006)

Conformational change of bacteriorhodopsin quantitatively monitored by microcantilever sensors

Braun, T., Backmann, N., Vögtli, M., Bietsch, A., Engel, A., Lang, H.-P., Gerber, Ch., M. Hegner

Biophysical Journal 90(8), 2970-2977 (2006)

Cryo-electron microscopy analysis of a 105 kDa protein particle: the xylulose kinase from E. coli

Chou, H.-T., di Luccio, E., Wilson, D., Stahlberg, H.

Microscopy and Microanalysis 12(Supp 2), 408-409 (2006)

Nano-dispensing by electrospray for biotechnology

Kuil, M. E., Abrahams, J., Marijnissen, J. C.

Biotechnol J 1(9), 969-75 (2006)

A homotetrameric kinesin-5, KLP61F, bundles microtubules and antagonizes Ncd in motility assays

Tao, L., Mogilner, A., Civelekoglu-Scholey, G., Wollman, R., Evans, J., Stahlberg, H., Scholey, J. M.

Curr Biol 16(23), 2293-302 (2006)

Bacterial outer membrane secretin PulD assembles and inserts into the inner membrane in the absence of its pilotin

Guilvout, I., Chami, M., Engel, A., Pugsley, A. P., Bayan, N.

EMBO J 25(22), 5241-9 (2006)

Biological scanning transmission electron microscopy: imaging and single molecule mass determination

Müller, S., Engel, A.

CHIMIA 60(11), 749-753 (2006)

Structure of the E-coli signal recognition particle bound to a translating ribosome

Schaffitzel, C., Oswald, M., Berger, I., Ishikawa, T., Abrahams, J., Koerten, H. K., Koning, R. I., Ban, N.

Nature 444(7118), 503-506 (2006)

The core of tau-paired helical filaments studied by scanning transmission electron microscopy and limited proteolysis

von Bergen, Martin, Barghorn, Stefan, Müller, S., Pickhardt, Marcus, Biernat, Jacek, Mandelkow, Eva-Maria, Davies, Peter, Aebi, U., Mandelkow, Eckhard

Biochemistry 45(20), 6446-57 (2006)

Cytotoxin ClyA from Escherichia coli assembles to a 13-meric pore independent of its redox-state

Eifler, N., Vetsch, M., Gregorini, M., Ringler, P., Chami, M., Philippsen, A., Fritz, A., Müller, S., Glockshuber, R., Engel, A., Grauschopf, U.

EMBO J 25(11), 2652-61 (2006)

The impact of single amino acid substitutions in CD3 gamma on the CD3 epsilon gamma interaction and T-cell receptor-CD3 complex formation

Thomassen, E. A. J., Dekking, E. H. A., Thompson, A., Franken, K. L., Sanal, O., Abrahams, J., van Tol, M. J. D., Koning, F.

Hum Immunol 67(8), 579-588 (2006)

Double hexameric ring assembly of the type III protein translocase ATPase HrcN

Müller, S., Pozidis, C., Stone, R., Meesters, C., Chami, M., Engel, A., Economou, A., Stahlberg, H.

Mol Microbiol 61(1), 119-25 (2006)

Functional modulation of IFT kinesins extends the sensory repertoire of ciliated neurons in Caenorhabditis elegans

Evans, J. E., Snow, J. J., Gunnarson, A. L., Ou, G., Stahlberg, H., McDonald, K. L., Scholey, J. M.

J Cell Biol 172(5), 663-9 (2006)

Type III secretion how Yersinia pestis infects its host

Müller, C. A., Broz, P., Cornelis, G. R., Müller, S., Engel, A.

BIOforum Eur 10(4), 40-42 (2006)

Immunogenicity and structural characterisation of an in vitro folded meningococcal siderophore receptor (FrpB, FetA)

Kortekaas, J., Müller, S., Ringler, P., Gregorini, M., Weynants, . E., Rutten, l., Bos, Martine P., Tommassen, J.

Microbes and Infection 8(8), 2145-2153 (2006)

Impact of disease mutations on the desmin filament assembly process

Bar, H., Mucke, N., Ringler, P., Müller, S., Kreplak, L., Katus, H. A., Aebi, U., Herrmann, H.

J Mol Biol 360(5), 1031-42 (2006)

Milestones in electron crystallography

Renault, L., Chou, H. T., Chiu, P. L., Hill, R. M., Zeng, X., Gipson, B., Zhang, Z. Y., Cheng, A., Unger, V., Stahlberg, H.

J Comput Aided Mol Des 20(42193), 519-27 (2006)

Molecular anatomy of a trafficking organelle

Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Gronborg, M., Riedel, D., Urlaub, H., Schenck, S, Bruegger, B., Ringler, P., Müller, S., Rammner, B., Graeter, F., Hub, J. S., De Groot, B. L., Mieskes, G., Moriyama, Y.

Cell 127(4), 831-846 (2006)

Applications of Atomic Scale Scanning Transmission Electron Microscopy

Browning, N.D., Erni, R., Mitterbauer, C.J., Fu, L., Chi, M., Mehraeen, S., Herrera, M., Chou, H.-T., Stahlberg, H., Ramasse, Q.M., Ziegler, A., Nicotra, G., Arslan, I., Idrobo, J.-C., Stach, E.A., Bleiloch, A.

Microscopy and Microanalysis 12(S02), 134-135 (2006)

Conformation-specific antibodies reveal distinct actin structures in the nucleus and the cytoplasm

Schoenenberger CA., Buchmeier S., Boerries M., Sütterlin, R., Aebi U., Jockusch BM.

J. Struct. Biol. 152(3), 157-68 (2005)

Micromechanical mass sensors for biomolecular detection in a physiological environment

Braun, T., Barwich, V., Ghatkesar, M. K., Bredekamp, A. H., Gerber, C., Hegner M., H.P. Lang

Phys Rev E Stat Nonlin Soft Matter Phys. 72(3 PT1), 031907 (2005)

The 5 Å structure of heterologously expressed plant aquaporin SoPIP2;1

Kukulski, W., Schenk, A., Johanson, U., Braun, T., de Groot, B., Fotiadis, D., Kjellbom P., A. Engel

J Mol Biol. 350(4), 611-6 (2005)

Effects of scaffold composition and architecture on human nasal chondrocyte redifferentiation and cartilaginous matrix deposition

Miot S., Woodfield T., Daniels AU., Sütterlin, R., Peterschmitt I., Heberer M., van Blitterswijk CA., Riesle J., Martin I.

Biomaterials 26(15), 2479-89 (2005)

Testing 3-D Reconstruction Methods for Electron Tomography

Mehraeen, S., Stahlberg, H., Evans, J. E., Meesters, C., Arslan, I., Midgley, P.A., Browning, N. D.

Microscopy and Microanalysis 11(S02), 336-337 (2005)

Reconstitution of two recombinant LSm protein complexes reveals aspects of their architecture, assembly, and function

Zaric, B., Chami, M., Remigy, H., Engel, A., Ballmer-Hofer, K., Winkler, F. K., Kambach, C.

J Biol Chem 280(16), 16066-75 (2005)

Relevance of apoptin's integrity for its functional behavior

Rohn, J. L., Zhang, Y. H., Leliveld, S. R., Danen-van Oorschot, A. A. A. M., Henriquez, N. V., Abrahams, J., Noteborn, M. H. M.

J Virol 79(2), 1337-1338 (2005)

Structural insights into the secretin PulD and its trypsin-resistant core

Chami, M., Guilvout, I., Gregorini, M., Remigy, H. W., Müller, S., Valerio, M., Engel, A., Pugsley, A. P., Bayan, N.

J Biol Chem 280(45), 37732-41 (2005)

Structural rearrangements in tubulin following microtubule formation

Krebs, A., Goldie, K., Hoenger, A.

EMBO Rep 6(3), 227-32 (2005)

Characterization of the in vitro co-assembly process of the intermediate filament proteins vimentin and desmin: mixed polymers at all stages of assembly

Wickert. U., Mücke, N., Wedig, T., Müller, S., Aebi, U., Herrmann, H.

Eur J Cell Biol 84(42038), 379-91 (2005)

The 4.5 Å structure of human AQP2

Schenk, A. D., Werten, P. J., Scheuring, S., de Groot, B. L., Müller, S., Stahlberg, H., Philippsen, A., Engel, A.

J Mol Biol 350(2), 278-89 (2005)

The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae

Tropis, M., Meniche, X., Wolf, A., Gebhardt, H., Strelkov, S., Chami, M., Schomburg, D., Kramer, R., Morbach, S., Daffe, M.

J Biol Chem 280(28), 26573-85 (2005)

The protein structure of recombinant human lactoferrin produced in the milk of transgenic cows closely matches the structure of human milk-derived lactoferrin

Thomassen, E. A. J., van Veen, H. A., van Berkel, P. H. C., Nuijens, J. H., Abrahams, J.

Transgenic Research 14(4), 397-405 (2005)

The V-antigen of Yersinia forms a distinct structure at the tip of injectisome needles

Müller, C. A., Broz, P., Müller, S., Ringler, P., Erne-Brand, F., Sorg, I., Kuhn, M., Engel, A., Cornelis, G. R.

Science 310(5748), 674-6 (2005)

FCS in non-ideal solutions

Schmauder, R., van Rijn, R., Abrahams, J., Kuil, M. E., Schmidt, T.

Biophys J 88(1), 655A-655A (2005)

Functional and structural characterization of the minimal Sec translocase of the hyperthermophile Thermotoga maritime

Pretz, M. G., Remigy, H., Swaving, J., Albers, S. V., Garrido, V. G., Chami, M., Engel, A., Driessen, A. J.

Extremophiles 9(4), 307-16 (2005)

Trimeric structure of OprN and OprM efflux proteins from Pseudomonas aeruginosa, by 2D electron crystallography

Lambert, O., Benabdelhak, H., Chami, M., Jouan, L., Nouaille, E., Ducruix, A., Brisson, A.

J Struct Biol 150(1), 50-7 (2005)

Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C

Dube, Prakash, Herzog, Franz, Gieffers, Christian, Sander, Bjoern, Riedel, Dietmar, Müller, S., Engel, A., Peters, Jan-Michael, Stark, Holger

Mol Cell 20(6), 867-879 (2005)

Molecular architecture and assembly mechanism of Drosophila tripeptidyl peptidase II

Rockel, B., Peters, J., Müller, S., Seyit, G., Ringler, P., Hegerl, R., Glaeser, R. M., Baumeister, W.

Proc Natl Acad Sci U S A 102(29), 10135-40 (2005)

Multiple assembly pathways underlie amyloid-beta fibril polymorphisms

Goldsbury, Claire, Frey, P., Olivieri, Vesna, Aebi, U., Müller, S.

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Structural analysis and evidence for dynamic emergence of Bacillus anthracis S-layer networks

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STEM analysis of Caenorhabditis elegant muscle thick filaments: evidence for microdifferentiated substructures

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Structural characterization of two aquaporins isolated from native spinach leaf plasma membranes

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Matrix methods for solving protein substructures of chlorine and sulfur from anomalous data

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J Struct Biol 132(2), 133-41 (2000)

The human Rad52 protein exists as a heptameric ring

Stasiak, Alicja Z., Larquet, Eric, Stasiak, Andrzej, Müller, S., Engel, A., Van Dyck, Eric, West, Stephen C., Egelman, Edward H.

Curr Biol 10(6), 337-340 (2000)

Domain structure of secretin PulD revealed by limited proteolysis and electron microscopy

Nouwen, N., Stahlberg, H., Pugsley, A. P., Engel, A.

EMBO J 19(10), 2229-36 (2000)

The regulatory complex of Drosophila melanogaster 26S proteasomes. Subunit composition and localization of a deubiquitylating enzyme

Holzl, H., Kapelari, B., Kellermann, J., Seemuller, E., Sumegi, M., Udvardy, A., Medalia, O., Sperling, J., Müller, S., Engel, A., Baumeister, W.

J Cell Biol 150(1), 119-30 (2000)

Use of detergents in two-dimensional crystallization of membrane proteins

Rigaud, J., Chami, M., Lambert, O., Levy, D., Ranck, J.

Biochim Biophys Acta 1508(42006), 112-28 (2000)

The reaction centre from green sulphur bacteria Chlorobium tedium: a structural analysis by scanning transmission electron microscopy

Remigy, H. W., Stahlberg, H., Fotiadis, D., Müller, S., Wolpensinger, B., Engel, A., Hauska, G., Tsiotis, G.

J Mol Biol 290(4), 851-858 (1999)

Three-dimensional visualization of cytoskeleton by confocal laser scanning microscopy

Baschong W., Duerrenberger M., Mandinova A., Sütterlin, R.

Methods Enzymol (307), 173-89 (1999)

Novel molecular architecture of the multimeric archaeal PEP-synthase homologue (MAPS) from Staphylothermus marinus

Cicicopol, Christiana, Peters, Jurgen, Lupas, Andrei, Cejka, Zdenka, Müller, S., Golbik, Ralph, Pfeifer, Gunter, Lilie, Hauke, Engel, A., Baumeister, Wolfgang

J Mol Biol 290(1), 347-361 (1999)

Crystal structure of the C-terminal SH2 domain of the p85alpha regulatory subunit of phosphoinositide 3-kinase: an SH2 domain mimicking its own substrate (Erratum in 294(3), 825-825 (1999))

Hoedemaeker, F. J., Siegal, G., Roe, S. M., Driscoll, P. C., Abrahams, J.

J Mol Biol 292(4), 763-70 (1999)

S-layer protein production by Corynebacterium strains is dependent on the carbon source

Soual-Hoebeke, E., de Sousa-D'Auria, C., Chami, M., Baucher, M. F., Guyonvarch, A., Bayan, N., Salim, K., Leblon, G.

Microbiology 145 ( Pt 12), 3399-408 (1999)

Calcium-mediated structural changes of native nuclear pore complexes monitored by time-lapse atomic force microscopy

Stoffler, D., Goldie, K., Feja, B., Aebi, U.

J Mol Biol 287(4), 741-52 (1999)

Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography

Ringler, P., Borgnia, M. J., Stahlberg, H., Maloney, P. C., Agre, P., Engel, A.

J Mol Biol 291(5), 1181-90 (1999)

Surface structures of native bacteriorhodopsin depend on the molecular packing arrangement in the membrane

Müller, D.J., Sass, H.J., Müller, S., Buldt, G., Engel, A.

J Mol Biol 285(5), 1903-1909 (1999)

Erratum for 'Crystal structure of the C-terminal SH2 domain of the p85 alpha regulatory subunit of phosphoinositide 3-kinase: An SH2 domain mimicking its own substrate' (vol 292, pg 763, 1999)

Hoedemaeker, F. J., Siegal, G., Roe, S. M., Driscoll, P. C., Abrahams, J.

J Mol Biol 294(3), 825-825 (1999)

Crystal structure of wildtype alpha(1)-antitrypsin

Elliott, P. R., Abrahams, J., Lomas, D. A.

American Journal of Respiratory and Critical Care Medicine 159(3), A192-A192 (1999)

Domain organization of Mac-2 binding protein and its oligomerization to linear and ring-like structures

Müller, S., Sasaki, T., Bork, P., Wolpensinger, B., Schulthess, T., Timpl, R., Engel, A., Engel, J.

J Mol Biol 291(4), 801-13 (1999)

Electrostatically balanced subnanometer imaging of biological specimens by atomic force microscope

Müller, D. J., Fotiadis, D., Scheuring, S., Müller, S., Engel, A.

Biophys J 76(2), 1101-1111 (1999)

Two-dimensional crystallization of Escherichia coli lactose permease

Zhuang, J., Prive, G. G., Werner, G. E., Ringler, P., Kaback, H. R., Engel, A.

J Struct Biol 125(1), 63-75 (1999)

High resolution AFM topographs of the Escherichia coli water channel aquaporin Z

Scheuring, S., Ringler, P., Borgnia, M., Stahlberg, H., Muller, D. J., Agre, P., Engel, A.

EMBO J 18(18), 4981-7 (1999)

Imaging streptavidin 2D crystals on biotinylated lipid monolayers at high resolution with the atomic force microscope

Scheuring, S., Muller, D. J., Ringler, P., Heymann, J. B., Engel, A.

J Microsc 193(1), 28-35 (1999)

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits

Stahlberg, H., Kutejova, E., Suda, K., Wolpensinger, B., Lustig, A., Schatz, G., Engel, A., Suzuki, C. K.

Proc Natl Acad Sci U S A 96(12), 6787-90 (1999)

The reaction centre of the photounit of Rhodospirillum rubrum is anchored to the light-harvesting complex with four-fold rotational disorder

Stahlberg, H., Dubochet, J., Vogel, H., Ghosh, R.

Photosynthesis Research 55, 363-368 (1998)

New developments in phase refinement

Abrahams, J., De Graaff, R. A. G.

Current Opin Struct Biol 8(5), 601-605 (1998)

A distinct membrane current in rat lens fiber cells isolated under calcium-free conditions

Eckert, R., Donaldson, P., Goldie, K., Kistler, J.

Invest Ophthalmol Vis Sci 39(7), 1280-5 (1998)

A revised model for the oligomeric state of the N-ethylmaleimide-sensitive fusion protein, NSF

Fleming, Karen G., Hohl, Tobias M., Yu, Richard C., Müller, S., Wolpensinger, B., Engel, A., Engelhardt, Harald, Brunger, Axel T., Sollner, Thomas H., Hanson, Phyllis I.

J Biol Chem 273(25), 15675-15681 (1998)

A supraspliceosome model for large nuclear ribonucleoprotein particles based on mass determinations by scanning transmission electron microscopy

Müller, S., Wolpensinger, B., Angenitzki, Mina, Engel, A., Sperling, Joseph, Sperling, Ruth

J Mol Biol 283(2), 383-394 (1998)

Reconstitution, characterisation and mass analysis of the pentacylindrical allophycocyanin core complex from the cyanobacterium Anabaena sp. PCC 7120

Ducret, A., Müller, S., Goldie, K., Hefti, A., Sidler, W. A., Zuber, H., Engel, A.

J Mol Biol 278(2), 369-88 (1998)

Are the light-harvesting I complexes from Rhodospirillum rubrum arranged around the reaction centre in a square geometry?

Stahlberg, H., Dubochet, J., Vogel, H., Ghosh, R.

J Mol Biol 282(4), 819-31 (1998)

Characterization of ARC, a divergent member of the AAA ATPase family from Rhodococcus erythropolis

Wolf. S., Nagy, I., Lupas, A., Pfeifer, G., Cejka, Z., Müller, S., Engel, A., De Mot, R., Baumeister, W.

J Mol Biol 277(1), 13-25 (1998)

Evaluating atomic models of F-actin with an undecagold-tagged phalloidin derivative

Steinmetz, M. O., Stoffler, D., Müller, S., Jahn, W., Wolpensinger, B., Goldie, K., Engel, A., Faulstich, H., Aebi, U.

J Mol Biol 276(1), 42010 (1998)

Evidence for the association of three FMO subunits per reaction center of Chlorobium tedium by scanning transmission electron microscopy

Remigy, H., Fotiadis, D., Hauska, G., Wolpensinger, B., Müller, S., Engel, A., Tsiotis, G.

1, 531-534 (1998)

Friction anisotropy and asymmetry of a compliant monolayer induced by a small molecular tilt

Liley, M., Gourdon, D., Stamou, D., Meseth, U., Fischer, T. M., Lautz, C., Stahlberg, H., Vogel, H., Burnham, N. A., Duschl, C.

Science 280(5361), 273-5 (1998)

High resolution microscopies of biomolecules in vacuum, ice or water

Engel, A., Walz, T., Müller, S., Heymann, J. B., Müller, D. J.

1, 42320 (1998)

Implications for function and therapy of a 2.9 angstrom structure of binary-complexed antithrombin

Skinner, R., Chang, W. S. W., Jin, L., Pei, X., Huntington, J. A., Abrahams, J., Carrell, R. W., Lomas, D. A.

J Mol Biol 283(1), 42261 (1998)

Wild-type alpha 1-antitrypsin is in the canonical inhibitory conformation

Elliott, P. R., Abrahams, J., Lomas, D. A.

J Mol Biol 275(3), 419-25 (1998)

Interaction of monomeric and dimeric kinesin with microtubules

Thormahlen, M., Marx, A., Müller, S., Song, Y. H., Mandelkow, E. M., Aebi, U., Mandelkow, E.

J Mol Biol 275(5), 795-809 (1998)

Late events in the assembly of 20S proteasomes

Mayr, J., Seemüller, E., Müller, S., Engel, A., Baumeister, W.

J Struct Biol 124(42038), 179-88 (1998)

Mass measurement in the scanning transmission electron microscope: A powerful tool for studying membrane proteins

Müller, S., Engel, A.

J Struct Biol 121(2), 219-230 (1998)

Visualization of prosomes (MCP-proteasomes), intermediate filament and actin networks by "instantaneous fixation" preserving the cytoskeleton

Arcangeletti C., Sütterlin, R., Aebi U., De Conto F., Missorini S., Chezzi C., Scherrer K.

J Struct Biol. 119(1), 35-58 (1997)

Punch-wounded, fibroblast populated collagen matrices: a novel approach for studying cytoskeletal changes in three dimensions by confocal laser scanning microscopy

Baschong W., Sütterlin, R., Aebi U.

Eur J Cell Biol. 72(3), 189-201 (1997)

A correlative analysis of actin filament assembly, structure, and dynamics

Steinmetz, M. O., Goldie, K., Aebi, U.

J Cell Biol 138(3), 559-74 (1997)

Polymorphic fibrillar assembly of human amylin

Goldsbury, C. S., Cooper, G. J., Goldie, K., Müller, S., Saafi, E. L., Gruijters, W. T., Misur, M. P., Engel, A., Aebi, U., Kistler, J.

J Struct Biol 119(1), 17-27 (1997)

Purification of the nicotinic acetylcholine receptor protein by affinity chromatography using a regioselectively modified and reversibly immobilized alpha-toxin from Naja nigricollis

Ringler, P., Kessler, P., Menez, A., Brisson, A.

Biochim Biophys Acta 1324(1), 37-46 (1997)

Reconstitution of FhuA, an Escherichia coli outer membrane protein, into liposomes. Binding of phage T5 to Fhua triggers the transfer of DNA into the proteoliposomes

Plancon, L., Chami, M., Letellier, L.

J Biol Chem 272(27), 16868-72 (1997)

Structural analysis of photosystem II: comparative study of cyanobacterial and higher plant photosystem II complexes

Hasler, Lorenz, Ghanotakis, Demetrios, Fedtke, Bettina, Spyridaki, Aspasia, Miller, Mette, Müller, S., Engel, A., Tsiotis, Georgios

J Struct Biol 119(3), 273-283 (1997)

Bias reduction in phase refinement by modified interference functions: introducing the gamma correction

Abrahams, J.

Acta Crystallogr D Biol Crystallogr 53(Pt 4), 371-6 (1997)

Structural mobility of antithrombin and its modulation by heparin

Carrell, R., Skinner, R., Jin, L., Abrahams, J.

Thromb Haemost 78(1), 516-9 (1997)

Chloroplast F0F1 ATP synthase imaged by atomic force microscopy

Neff, D., Tripathi, S., Middendorf, K., Stahlberg, H., Butt, H. J., Bamberg, E., Dencher, N. A.

J Struct Biol 119(2), 139-48 (1997)

The 2.6 Angstrom structure of antithrombin indicates a conformational change at the heparin binding site

Skinner, R., Abrahams, J., Whisstock, J. C., Lesk, A. M., Carrell, R. W., Wardell, M. R.

J Mol Biol 266(3), 601-609 (1997)

The anticoagulant activation of antithrombin by heparin

Jin, L., Abrahams, J., Skinner, R., Petitou, M., Pike, R. N., Carrell, R. W.

Proc Natl Acad Sci U S A 94(26), 14683-8 (1997)

The ATP-dependent HslVU protease from Escherichia coli is a four-ring structure resembling the proteasome

Rohrwild, Markus, Pfeifer, Guenter, Santarius, Ute, Müller, S., Huang, H. C., Engel, A., Baumeister, Wolfgang, Goldberg, Alfred L.

Nature Struct Biol 4(2), 133-139 (1997)

The crystal structure of the nucleotide-free alpha 3 beta 3 subcomplex of F-1-ATPase from the thermophilic Bacillus PS3 is a symmetric trimer

Shirakihara, Y., Leslie, A. G. W., Abrahams, J., Walker, J. E., Ueda, T., Sekimoto, Y., Kambara, M., Saika, K., Kagawa, Y., Yoshida, M.

Structure 5(6), 825-836 (1997)

The S-layer protein of Corynebacterium glutamicum is anchored to the cell wall by its C-terminal hydrophobic domain

Chami, M., Bayan, N., Peyret, J. L., Gulik-Krzywicki, T., Leblon, G., Shechter, E.

Mol Microbiol 23(3), 483-92 (1997)

Improved diffraction of antithrombin crystals grown in microgravity

Wardell, M. R., Skinner, R., Carter, D. C., Twigg, P. D., Abrahams, J.

Acta Crystallogr D Biol Crystallogr 53(Pt 5), 622-5 (1997)

Mass determination by inelastic electron scattering in an energy-filtering transmission electron microscope with slow-scan CCD camera

Feja, Bernhard, Durrenberger, Markus, Müller, S., Reichelt, Rudolf, Aebi, U.

J Struct Biol 119(1), 72-82 (1997)

Mass determination, subunit organization and control of oligomerization states of keyhole limpet hemocyanin (KLH)

Söhngen, S.M., Stahlmann, A., Harris, J.R., Müller, S., Engel, A., Markl, J.

Eur J Biochem 248(2), 602-614 (1997)

Molecular biology of S-layers

Bahl, H., Scholz, H., Bayan, N., Chami, M., Leblon, G., Gulik-Krzywicki, T., Shechter, E., Fouet, A., Mesnage, S., Tosi-Couture, E., Gounon, P., Mock, M., Conway de Macario, E., Macario, A. J., Fernandez-Herrero, L. A., Olabarria, G., Berenguer, J., Blaser, M. J., Kuen, B., Lubitz

FEMS Microbiol Rev 20(42006), 47-98 (1997)

Sulphur-bearing lipids for the covalent attachment of supported lipid bilayers to gold surfaces: a detailed characterisation and analysis

Duschl, C., Liley, M., Lang, J, Ghandi, A., Zakeeruddin, S.M., Stahlberg, H., Dubochet, J., Nemetz, A., Knoll, W., Vogel, H.

Materials Science & Engineering C 4, 7-18 (1996)

Structural studies on the 2.25-MDa homomultimeric phosphoenolpyruvate synthase from Staphylothermus marinus

Harauz, G., Cicicopol, C., Hegerl, R., Cejka, Z., Goldie, K., Santarius, U., Engel, A., Baumeister, W.

J Struct Biol 116(2), 290-301 (1996)

Structure and assembly properties of the intermediate filament protein vimentin: the role of its head, rod and tail domains

Herrmann, H., Haener, Markus, Brettel, Monika, Müller, S., Goldie, K., Fedtke, Bettina, Lustig, Ariel, Franke, Werner W., Aebi, U.

J Mol Biol 264(5), 933-953 (1996)

The structure of bovine F-1-ATPase complexed with the antibiotic inhibitor aurovertin B

vanRaaij, M. J., Abrahams, J., Leslie, A. G. W., Walker, J. E.

Proc Natl Acad Sci U S A 93(14), 6913-6917 (1996)

The structure of bovine mitochondrial F1-ATPase - An insight into ATP synthesis

Abrahams, J., Leslie, A. G. W., Lutter, R., Walker, J. E.

Biophys J 70(2), Mams3-Mams3 (1996)

Filensin and phakinin form a novel type of beaded intermediate filaments and coassemble de novo in cultured cells

Goulielmos, George, Gounari, Fotini, Remington, Susann, Müller, S., Haener, Markus, Aebi, U., Georgatos, Spyros D.

J Cell Biol 132(4), 643-55 (1996)

Two-dimensional structure of membrane-bound nitrite oxidoreductase from Nitrobacter hamburgensis

Spieck, E., Müller, S., Engel, A., Mandelkow, E., Patel, H., Bock, E.

J Struct Biol 117(2), 117-123 (1996)

Inhibitory conformation of the reactive loop of alpha 1-antitrypsin

Elliott, P. R., Lomas, D. A., Carrell, R. W., Abrahams, J.

Nat Struct Biol 3(8), 676-81 (1996)

Methods used in the structure determination of bovine mitochondrial F-1 ATPase

Abrahams, J., Leslie, A. G. W.

Acta Crystallogr D Biol Crystallogr 52, 30-42 (1996)

Organization of the outer layers of the cell envelope of Corynebacterium glutamicum: a combined freeze-etch electron microscopy and biochemical study

Chami, M., Bayan, N., Dedieu, J., Leblon, G., Shechter, E., Gulik-Krzywicki, T.

Biol Cell 83(42038), 219-229 (1995)

A quantitative electrophoretic migration shift assay for analyzing the specific binding of proteins to lipid ligands in vesicles or micelles

Arnold, M., Ringler, P., Brisson, A.

Biochim Biophys Acta 1233(2), 198-204 (1995)