Transmembrane proteins play an important role in many signaling pathways and the exchange of material across the membrane. Many are considered to be are important pharmaceutical targets.
 The intracellular concentration of calcium ions controls multiple physiological processes, such as muscle contraction, cell proliferation, and release of neurotransmitters. Diverse Ca2+ transporters and pumps act in concert to restore the low resting concentration of calcium (~100nM) in order to prevent damage to the cell due to Ca²⁺ overload. By analyzing the 3-D structure a Ca²⁺-antiporter we are trying to obtain a better understanding of how cells establish the Ca²⁺ resting concentration. In a collaborative effort, we are also investigating the structure of a transporter complex.

Related Publications

Raphael Kueng

Mark Hilger

Supervisor until Aug. 2015 

Contact

Henning Stahlberg

Key Publication

Protein Crystallization Center - PCC (UZH)

Swiss Lightsource SLS (PSI)

Philips CM10

Philips CM200FEG